Study Reveals Why Black Americans Face Higher Tardive Dyskinesia Risk
A study shows the increased risk of tardive dyskinesia (TD) among Black individuals in the United States compared with White individuals. The study identifies contributing factors, including health disparities and specific genetic traits in Black populations, which slow down the metabolism of drugs like antipsychotics, elevating TD risk. Moreover, the prescription pattern of first-generation antipsychotics, more strongly linked to TD, to Black Americans by doctors is highlighted. The researchers emphasize the importance of open communication between patients and healthcare providers, especially for those at risk, and highlight the critical role of monitoring medication usage, dosage, and treatment duration in TD symptom management.
Study Finds Patient Perception of Tardive Dyskinesia’s Impact Differs From Clinician Assessment
Researchers of a study examined the impact of tardive dyskinesia (TD) patient health and social functioning, conducted in two cohorts: Cohort 1 consisted of patients with no abnormal involuntary movements, while Cohort 2 consisted of patients with possible TD according to clinicians’ judgment. The assessments included measuring health utility using EuroQoL’s EQ-5D-5L, social functioning using the Sheehan Disability Scale (SDS), as well as patient- and clinician-rated severity and impact of TD.
The results showed that in Cohort 2, patient-rated TD impact was significantly associated with lower health utility and higher SDS scores. However, clinician-rated severity was moderately associated with both health utility and SDS, but these associations were not statistically significant. The study concluded that the severity of TD assessed by clinicians did not always correlate with patient perceptions of the significance of TD.
Link Between Antidepressants and Tardive Dyskinesia Explored
In a recent study, researchers critiqued various reviews and case reports associating non-dopamine-receptor-blocking drugs (DRBDs) with a tardive dyskinesia (TD) like syndrome, examining if the cases met TD criteria and excluded DRBD use. Their findings indicate that both tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitor antidepressants (SSRIs) may reveal or worsen TD in individuals previously exposed to or using DRBDs; however, they found minimal evidence supporting TD’s existence outside of this context.
Researchers Examine Effectiveness of VMAT2 Inhibitors in Treating Tardive Dyskinesia
Researchers of a study examined the effectiveness of vesicular monoamine transporter-2 (VMAT2) inhibitors and other agents in light of different theories regarding the development of tardive dyskinesia (TD).
Understanding Tardive Dyskinesia
The author of this article gives an overview of tardive dyskinesia (TD). TD can potentially be a permanent movement disorder that is caused by dopamine receptor blocking agents (DRBAs) in chronically using them. There are several risk factors associated with TD including certain genetic factors, female sex, African and Caucasian ethnicity, older age, illness duration along with cumulative dose of DRBA, and use of first-generation antipsychotics. Approximately 25% of psychiatric patients taking antipsychotic medication are estimated to have TD, representing a minority compared with the amount of people taking these medications. Prevention of TD is crucial, as stopping the medication causing TD does not always relieve the condition; however, there is no certain way to predict who will develop TD once starting DRBA use.
Authors Review Impact of Calcium Channel Blockers on Antipsychotic-Induced Tardive Dyskinesia
Authors of a review looked to study the impact of calcium channel blocker therapies (diltiazem, nifedipine, nimodipine, verapamil) in treating patients with neuroleptic-induced tardive dyskinesia (TD) and chronic mental illnesses including schizophrenia and schizoaffective disorder. Researchers used the Cochrane Schizophrenia Group Trials Register (July 2015 and April 2017) to gather information for their research. There were no trials included in prior versions of this review. In their 2015 review, there were three cross-over trials that were included by the researchers, but no new relevant studies in the 2017 review. A total of 47 patients were included in the study from the included trials who had chronic mental illness from both the United States and China. Authors did note that, due to the low availability of evidence, no conclusions could be made on the impact of calcium channel blockers in antipsychotic-induced TD.
Insights on Treating Tardive Dyskinesia Using Telehealth
A panel of six neurologists, three psychiatrists, and three psychiatric nurse practitioners participated in a study to outline a framework to address the use of telehealth to treat tardive dyskinesia. The panel found telehealth to be beneficial primarily for the ease of making and attending appointments for patients but agreed that an in-person assessment should be held at least every six months from telehealth appointments. Additional recommendations are discussed.
How to Identify Tardive Dyskinesia: Learning the Movements
This video is an instructional guide to help providers and patients identify the facial movements that are most commonly associated with tardive dyskinesia (TD). The movements that patients with TD experience are slow, irregular, and change their shape. Through real time demonstrations, Dr Rajnish Mago shows multiple examples of the most common facial movements found in patients with TD including pouting, puckering, and smacking of the lips as well as several tongue, perioral, and jaw movements.
Tardive Dyskinesia: The Causes and Importance of Early Recognition
This video follows the real-life story of a patient with tardive dyskinesia (TD), while also providing an overview of the disease. TD is a late-onset movement disorder that has been linked to long-term use of antipsychotic medications. The physical symptoms can impact the entire body but are often most noticeable in the facial region. Challenges for providers are discussed, including how to weigh the use of antipsychotic therapies with the potential of TD in patients who have a history of medications, including therapies unrelated to mental health medications that are also dopamine blockers, and the importance of early symptom recognition by both patients and providers.
Tardive Dyskinesia and How the Nervous System Works
A video from the Depression and Bipolar Support Alliance discusses information about tardive dyskinesia (TD), as well as how the nervous system works. Some people do not have enough, too much, or irregular neurotransmitters to bind to receptors that can cause irregular signaling, possibly explaining the symptoms of mental health conditions including schizophrenia, bipolar disorder, and depression. In order to treat mental health conditions, antipsychotics are often given, and much of these therapies are dopamine-receptor blocking agents. More signaling can occur when dopamine is binding to hypersensitive dopamine receptors, having an impact on areas of the brain that impact motor function, causing TD.
