Clinical Efficacy of the Use or Withdrawal of Anticholinergic Drugs in Tardive Dyskinesia

This study analyzes data regarding the use and withdrawal of anticholinergic drugs (benzhexol, benztropine, biperiden, orphenadrine, procyclidine, scopolamine, or trihexyphenidyl) for the treatment of patients with tardive dyskinesia (TD; among other movement disorders). Researchers sought to determine if the use or removal of these drugs showed clinical effectiveness in treating those with antipsychotic-induced TD. It was determined that further studies are needed on the benefits of both the use and withdrawal of anticholinergic drugs for this population.

Reference: Bergman H, Soares-Weiser K. Anticholinergic medication for antipsychotic-induced tardive dyskinesia. Cochrane Database Syst Rev. 2018;1(1):CD000204. doi:10.1002/14651858.CD000204.pub2

Related Articles