This study analyzes data regarding the use and withdrawal of anticholinergic drugs (benzhexol, benztropine, biperiden, orphenadrine, procyclidine, scopolamine, or trihexyphenidyl) for the treatment of patients with tardive dyskinesia (TD; among other movement disorders). Researchers sought to determine if the use or removal of these drugs showed clinical effectiveness in treating those with antipsychotic-induced TD. It was determined that further studies are needed on the benefits of both the use and withdrawal of anticholinergic drugs for this population.

Reference: Bergman H, Soares-Weiser K. Anticholinergic medication for antipsychotic-induced tardive dyskinesia. Cochrane Database Syst Rev. 2018;1(1):CD000204. doi:10.1002/14651858.CD000204.pub2