Researchers of a study examined the impact of tardive dyskinesia (TD) patient health and social functioning, conducted in two cohorts: Cohort 1 consisted of patients with no abnormal involuntary movements, while Cohort 2 consisted of patients with possible TD according to clinicians’ judgment. The assessments included measuring health utility using EuroQoL’s EQ-5D-5L, social functioning using the Sheehan Disability Scale (SDS), as well as patient- and clinician-rated severity and impact of TD.

The results showed that in Cohort 2, patient-rated TD impact was significantly associated with lower health utility and higher SDS scores. However, clinician-rated severity was moderately associated with both health utility and SDS, but these associations were not statistically significant. The study concluded that the severity of TD assessed by clinicians did not always correlate with patient perceptions of the significance of TD.

Reference: Tanner CM, Caroff SN, Cutler AJ, Lenderking WR, Shalhoub H, Pagé V, Franey EG, Serbin M, Yonan C. Impact of possible tardive dyskinesia on physical wellness and social functioning: results from the real-world RE-KINECT study. J Patient Rep Outcomes. 2023 Mar 9;7(1):21. doi: 10.1186/s41687-023-00551-5.