Tardive dyskinesia (TD) is a potentially irreversible movement disorder caused by antipsychotic medications, marked by involuntary, repetitive movements that can significantly impair quality of life. This study aimed to assess how TD-related movements influence others’ perceptions in social and professional settings. Using a randomized, blinded digital survey, general population participants viewed videos of actors simulating either TD or no TD movements and then responded to questions related to employment, dating, and friendship. Separate assessments were conducted for mild-to-moderate and moderate-to-severe TD, with expert physicians confirming the authenticity and severity of the simulated movements using Abnormal Involuntary Movement Scale scores.

Researchers found that participants consistently responded more negatively to individuals displaying TD movements across all domains. Compared to control participants, those who viewed actors with TD movements were significantly less likely to consider them for employment, find them attractive, or express interest in friendship. This trend held true regardless of the severity of TD. The results suggest that visible TD symptoms may contribute to stigma, social isolation, and reduced life opportunities. As the first randomized study to quantify the social and professional consequences of TD, these findings highlight the need for increased awareness and strategies to address stigma in this population.

Reference: Ayyagari R, Goldschmidt D, Mu F, Caroff SN, Carroll B. An Experimental Study to Assess the Professional and Social Consequences of Tardive Dyskinesia. Clin Psychopharmacol Neurosci. 2022;20(1):154-166. doi: 10.9758/cpn.2022.20.1.154.